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Subject: [DCHAS-L] Ductless perchloric acid fume hoods???
Date: Wednesday, February 6, 2019 at 1:17:59 PM
Author: Dr Bob <drbob**At_Symbol_Here**FLOWSCIENCES.COM> 		Next by Date:
Subject: Re: [DCHAS-L] Ductless perchloric acid fume hoods???
Date: Wed, 6 Feb 2019 13:50:51 -0500
Author: Richard Palluzi

(Note: This post is 6 years old and may contain outdated information.)

From: Monona Rossol <0000030664c37427-dmarc-request**At_Symbol_Here**LISTS.PRINCETON.EDU>
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
Date: Wed, 6 Feb 2019 18:42:52 +0000
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: 943724785.4529009.1549478572445**At_Symbol_Here**mail.yahoo.com


Alan,

Maybe squatters should not move in next door to a chemical plant?
Can't believe you said this.  Go see.

And the lawsuits filed after and even still today have to do with continuing health issues and sensitization.  So this is another problem that won't go away until the last Bhopal victim, and perhaps their fist generation children are dead and gone.

Monona


-----Original Message-----
From: Alan Hall <oldeddoc**At_Symbol_Here**GMAIL.COM>
To: DCHAS-L <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Sent: Wed, Feb 6, 2019 1:02 pm
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)

Et al,

In general (not necessarily speccific to the compound in question), most isocyanurates are sensitizers.  This means that a single high-level airborne exposure can cause RADS (Reactive Airways Dysfunction Syndrome) or in others with more low-level chronic exposure, Occupational Asthma (there are specific published critera for this diagnosis), and there's a few who don't any meet all of the criteria and still are disabled.

That whole disaster in Bhopal was with MIC. I've had to review every bit of the data. It causes pulmonary edema which was fatal in many cases.  There was no cyanide release.  Maybe squatters should not move in next door to a chemical plant?  It was there first.  But a true tragedy and if a couple disgruntled employees had not done the wrong thing, it mght never have happened and the world would be a better place.

Free medical advice is worth exactly what you pay for it, but if I had worn your mocassins and walked a mile, I think I'd consult the folks at the Johns Hopkins in Baltimore and go from there.  Sir Osler founded the bedside teaching of medicine in America, and there's some darned good folks still there. There's some tests might done and maybe an improved treatment regimen.

Alan
Alan H. Hall, M.D.
Medical Toxicologist
Toxicology Consulting and Medical Translating Services
Springtown and Azle, Texas
Clinical Assistant Professor
Colorado School of Public Health
University of Colorado-Denver



On Wed, Feb 6, 2019 at 9:30 AM TILAK CHANDRA <0000058f112ac338-dmarc-request**At_Symbol_Here**lists.princeton.edu> wrote:
Isocyanates are also precursor for many pesticides. Methyl isocyanate (MIC) killed around 10,000 people in Bhopal in 1984 (Union carbide incident). It means some of the isocyanate can be lethal.
 
Tilak
 
From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU> On Behalf Of Monona Rossol
Sent: Tuesday, February 05, 2019 1:56 PM
To: DCHAS-L**At_Symbol_Here**PRINCETON.EDU
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
 
Of course it is.  We need to look at adopting the UK rules for this whole bunch of chemicals.  They don't care what isocyanate radical is attached to, it is regulated as a sensitizer whether it has actually been tested and found so or not.  

Monona Rossol, MS, MFA, Industrial Hygienist 
 
-----Original Message-----
From: Wisnewski, Adam <adam.wisnewski**At_Symbol_Here**YALE.EDU>
To: DCHAS-L <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Sent: Tue, Feb 5, 2019 2:47 pm
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
Here is a case series report JACI in Practice...It is a sensitizer 
 
 
Adam V Wisnewski, PhD
Senior Research Scientist 
Department Internal Medicine/Section General Medicine
Program in Occupational & Environmental Medicine
Yale School of Medicine
300 Cedar Street/PO Box 208057
Building: TACS420
New Haven, CT 06520-8057
203-737-4054 (lab)
203-645-5665 (cell)
 
From: Bello, Dhimiter <Dhimiter_Bello**At_Symbol_Here**uml.edu>
Sent: Tuesday, February 5, 2019 1:52 PM
To: Redlich, Carrie; Wisnewski, Adam
Subject: Fwd: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
 
This was on my draft folder=E2=80=A6
FYI
 
Sent from my iPhone
Please excuse typos and brevity.

Begin forwarded message:
From: Boitumelo Kgarebe <bkgarebe**At_Symbol_Here**GMAIL.COM>
Date: September 17, 2018 at 8:44:00 AM EDT
To: <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Dear Colleagues,
Our Occupational Medicine clinic saw two patients who were from the same company, performing the same duties, namely powder spray coating using a chemical called triglycidyl isocyanurate (TGIC).  They were  assessed and the clinic seemed convinced that this chemical is a sensitizer, causing their occupational condition.   
A factory visit to understand exposures and associated occupational setting well, was also undertaken .  The process observed was similar to what is described in literature. 
The Factory Management seems to be keen that we investigate this further, as they are adamant this chemical is not the likely cause of their respiratory (asthmatic) effects. Another point from the company is that the TGIC is actually bound to a resin thus not  active on its own as it is already in a bound state (not freely available).   
My question is: Is TGIC found in the sample/ that they use is freely available as a sensitiser? Are there other less harmful substitutes?
BVK
Dr Boitumelo V.  Kgarebe Phd(London) FAAS
Head: Analytical Services
25 Hospital Street, JHB 2001
National Institute for Occupational Health
National Health Laboratory Service
Tel: +27(0)11 712 6410   |  Mobile: +27(0)82 | Fax: +27(0) 712 6545
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