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Subject: [DCHAS-L] Butyl Lithium & syringe safety
Date: March 7, 2013 9:52:50 AM EST
Author: Kim Gates 		Next by Date:
Subject: Re: [DCHAS-L] Butyl Lithium & syringe safety
Date: March 7, 2013 11:51:54 AM EST
Author: "George D. McCallion"

(Note: This post is 12 years old and may contain outdated information.)

From: "George D. McCallion" <medchem**At_Symbol_Here**COMCAST.NET>
Subject: Re: [DCHAS-L] Butyl Lithium & syringe safety
Date: March 7, 2013 11:48:10 AM EST
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: <CAA4EBLtk1T8Dp=FGoE9QpNp67DjzTj2eyKjrnBHYuH7TQ0DGHA**At_Symbol_Here**mail.gmail.com>


Out of the gate, I would suggest going to the DCHAS-L webiste and examine the email database. there is a plethora of email traffic on this; some of which was provided by myself.

 

In answer to your questions, Kim...

 

1. Is there enough residual material in the syringe that it could be hazardous?
 
Absolutely! any residual BuLi is hazardous, period!
 
2. Should there be a sharps container stored in the fume hood for the exclusive use of these syringes (avoiding incompatible material that may be left in the syringe)
 
Yes. All one needs to do is havea beaker of Silicone oil nearby in the hood. After using the BuLi-poisoned syringe, draw up silione oil and discharge back into the beaker which houses the Silicone oil. Do this a few (3-5) times.
 
Afterwards, the syringe (AND NEEDLE!...if a leuer-lok system) can be rinsed with i-PrOH and then disposed of in normal fashion.
 
3. If not a sharps container, what/how does your labs dispose of these syringes?
 
We use a sharps container. Perform the rinsing steps described above.
 
Hope this helps!
 
-George
 

********************************

George D. McCallion

QA Reviewer, Quality and Compliance

QS Pharma, LLC

3 Chelsea Parkway, Suite 305

Boothwyn, PA 19061

Mobile: 610.888.2436

Office: 610.485.4270, ext. 245

George.McCallion**At_Symbol_Here**qspharma.com


From: "Kim Gates" <kim.gates**At_Symbol_Here**STONYBROOK.EDU>
To: DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU
Sent: Thursday, March 7, 2013 9:52:50 AM
Subject: [DCHAS-L] Butyl Lithium & syringe safety

I have a question from our Chem dept about nButyl Lithium & syringes after I forwarded them the CEN blog on safer syringes. http://cenblog.org/the-safety-zone/2013/02/engineering-safer-syringes/  


The lab's SOP calls for not reusing their syringes & only filling them 50%. I asked them to write in more clearly that they are to dispose in sharps container. 

The questions I'm hoping any of you with similar hazards can help with:

1. Is there enough residual material in the syringe that it could be hazardous?
2. Should there be a sharps container stored in the fume hood for the exclusive use of these syringes (avoiding incompatible material that may be left in the syringe)
3. If not a sharps container, what/how does your labs dispose of these syringes? 

thanks!



Kim Gates
Laboratory Safety Specialist
Environmental Health & Safety
Stony Brook University
Stony Brook, NY 11794-6200
Kim.Gates**At_Symbol_Here**stonybrook.edu
631-632-3032
FAX: 631-632-9683
EH&S Web site: http://www.stonybrook.edu/ehs/lab/

Please note my name and email have changed.

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